Green Synthesis of Derivatives Of Coumarin Us...

Green Synthesis of Derivatives Of Coumarin Using Phosphotungsticacid (H3PW12O40) as an Effective Catalyst and study their anti inflammatory properties

Author Name : Dr. Anna Regini Anthony

ABSTRACT

The Chemists all over the globe are motivated not only for the environmentally benign synthesis of new products but also to develop green synthesis for existing chemicals. The Coumarin heterocyclic ring is a common feature of various bioactive compounds such as Calanolides, lipid lowering agents. Recent studies   have been revealed that coumarin and the derivatives exhibit several other medicinal applications. Phosphotungsticacid  (H₃PW₁₂O₄₀) is a commercially available environmentally benign catalyst non-toxic widely used for the synthesis of the substitutedcoumarins. The scope of this catalyst has not been fully explored, but can be used as buffer, neutralizing agent. Owing to the numerous advantages associated with cheap and non-hazardous catalyst, and also realizing g the importance of coumarin herein we would like to focus the green method for his synthesis of derivatives of coumarin using cheaper and commercially available acid Phosphotungsticacid  (H₃PW₁₂O₄₀)  and also by the Knoevenagel condensation under microwave irradiation.

All the derivaives of the coumarins were studied anti-inflammatory activity. Anti-inflammatory activity of the newly synthesised Coumarins has been evaluated by calculating the percentage protection or percentage inhibition which was calculated by following equation.

% protection= [O.D of control – O.D of test/ O.D of control x 100

Where O.D stands for optical density

This methodology offers significant improvements for the synthesis of derivatives of coumarins with regard to yield of products, simplicity in operation and green aspects by avoiding toxic conventional catalysts and solvents. The coupling of microwave heating with solid phase catalysts in solvent-free conditions  catalysis chemical processes with special attributes such as s enhanced reaction rate,  Therefore owing the importance of Phosphotungsticacid  (H₃PW₁₂O₄₀) a facile catalyst used for the green synthesis of derivatives of coumarin .

Keywords:Phosphotungsticacid, microwave irradiation, anti inflammatory