In Vivo Screening Methods Of Anti Inflammator...

In Vivo Screening Methods Of Anti Inflammatory Drugs: A Comprehensive Review

Author Name : M. Sreevidya, S. Tejasri, Gardas Shreya, Rangu Ujwala

ABSTRACT

Inflammation is a prevalent occurrence in the majority of acute and chronic debilitating diseases, and it is a leading source of morbidity in today's modern world. Inflammation causes rheumatoid arthritis, diabetes, cancer, Alzheimer's disease, and atherosclerosis, as well as respiratory, autoimmune, and cardiovascular disorders if left unchecked.. Inflammation is a multi-pathway process that involves a complex network of mediators, a variety of cells, and the execution of many pathways. Anti-inflammatory drugs, both steroidal and non-steroidal, are being used to treat inflammatory illnesses. New anti-inflammatory drugs with selective effect and lower toxicity are desperately needed. Plants and isolated phytoconstituents are potential and intriguing novel anti-inflammatories sources. Drug development from natural sources, on the other hand, has been hampered by issues such as the complexity of extracts and the difficulty of isolating pure phytoconstituents. Although there are a variety of in-vivo and in-vitro models for anti-inflammatory medication development, choosing the right animal models is a crucial step in the early stages of drug development. The identification and development of potential anti-inflammatory leads from natural sources can be aided by systematic examination of phytoconstituents. The current study discusses numerous anti-inflammatory drug screening methodologies, their benefits and drawbacks, as well as biological targets of phytoconstituents in inflammation and biomarkers for anti-inflammatory medication adverse effect prediction. The systematic strategy for anti-inflammatory drug screening presented in this research can justify the detection of novel phytoconstituents at the early stages of drug screening programmes. anti-inflammatory; phytoconstituents; biomarkers; drug discovery; animal models

Keywords: anti-inflammatory; phytoconstituents; drug discovery; animal models