Microwave Assisted Synthesis Of bis-1, 3, 4 -...

Microwave Assisted Synthesis Of bis-1, 3, 4 - oxadiazole Derivative

Author Name : Varsha V. Thorat

ABSTRACT

 In present work, 1,3-bis[5-(3-methoxy-4-hydroxy-5-nitrophenyl)-1,3,4- oxadiazol-2-yl]benzene has been prepared expeditiously using  microwave method.  Condensation of isopthalic acid dihydrazide and 5-nitrovanillin  gave the corresponding dihydrazone which on oxidative cyclisation with chloramines-T under microwave irradiation gave the corresponding 2,5- disubstituted-1,3,4-Oxadiazole. The product obtained is pure having yield 94%. The synthesized compound was characterized by FTIR and NMR spectroscopy.  The study reveals that oxidative transformation under microwave irradiaton is very clean and rapid method. The reaction conditions and the work up procedures are simple and mild.

Keywords:  bis-1,3,4-oxadiazole, chloramine-T, 5-nitrovanillin, dihydrazide