Network Pharmacology: A Paradigm Shift in the...

Network Pharmacology: A Paradigm Shift in the Field of Drug Discovery

Author Name : Mr Payaam Vohra, Mr Gaurav Pandey

ABSTRACT

Network pharmacology is an approach to drug design that encompasses systems biology, network analysis, connectivity and redundancy. Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs. The complex multi-component nature of medicinal herbs may serve as valuable resources for network-based multi-target drug discovery due to its potential treatment effects by synergy. With the aid of this novel process one can convert the orthodox concept of 1drug, 1 target, 1 disease into 1 drug, multiple targets and multiple diseases. Network pharmacology approaches can also be used to map the unexplored target space and therapeutic potential of natural products, providing a systematic means by which to extend the druggable space of proteins implicated in complex diseases and rare diseases. Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease and also hold a variety of bioactive scaffolds for the treatment of multiple disorders. For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline, while low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this. Precise and effective therapeutic intervention is achieved by synergistic multicompany network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.

Keywords: Network pharmacology, Paradigmshift, Drug discovery, Repurposing