Phytochemicals: Peroxisome proliferator-activ...

Phytochemicals: Peroxisome proliferator-activated receptor gamma (PPARγ) Agonistic Agents, a review

Author Name : Khan Sana, Singh Gurdeep

ABSTRACT The objective of this study was to explore the potential of selective PPARγ modulators that improve glucose homeostasis and reduced side effects as shown by full PPARγ agonist. Natural products prove to be a rich source for the discovery of novel PPARγ ligands and many structurally diverse agonists of this receptor were recently identified from traditionally used medicinal plants or food sources. Interestingly, the majority of identified natural compounds are rather weak agonists of PPARγ, often activating the receptor as partial agonists, with activation pattern distinct from the full thiazolidinedione agonists. A range of PPARγ activating natural products and plant extracts were recently described that bear a good potential to be further explored for therapeutic effectiveness as well as to be studied as potential dietary supplements to counteract the metabolic syndrome and type 2 diabetes.