Review Article on Formulation and Evaluation ...

Review Article on Formulation and Evaluation of Posaconazole Topical Gel

Author Name : Anand Gauro, Mrs. Archana Rautela, Ms. Karabi Kalita, Dr. Praveen Kumar Ashok

ABSTRACT Antifungal drugs are commonly used as a conventional delivery systemic treatment of infection. The efficacy of the drug depends on the penetration of the skin. The current research was focused on the development of a Topical Gel formulation of Posaconazole for the treatment of Fungal Infections. Posaconazole was approved by the food and drug administration for use as a prophylaxis agent for invasive aspergills and candida infection in the immune-compromised patient. It is the newest triazole antifungal agent. The Posaconazole topical gel was composed of Carbopol 934 and HPMC E 15 as polymers, which were neutralized by a sufficient quantity of Triethanolamine and Glycerine as a moistening agent. The optimized ratio of Drug and polymer was selected depending on the compatibility of the formulation. The effect of different concentrations of polymer and Posaconazole were studied. FTIR studies proved that there is no interaction between Posaconazole and used polymer, it was found compatible. The prepared Topical Gel was subjected to solubility studies, pH, stability, drug content, percentage yield, viscosity, in-vitro drug release, etc. The viscosity was found all-time up to 4000 cp and the pH is around 6 to 7.5 so it will be good for applying to the skin. Drug content was also found upper than 90 %, was proved that it can be a good medium to deliver drugs to the human body. In-vitro drug release studies were performed using Franz diffusion cells across dialysis membranes. The release drug profile gives good results in the time after starting the experiments; it proves that it might be a replacement for oral formulations.