Self-Emulsifying Drug Delivery Systems for Po...

Self-Emulsifying Drug Delivery Systems for Poorly Soluble Drugs

Author Name : Sanke Manasa, K. Anie Vijetha

ABSTRACT

Orally administered drug solubility is a serious concern for the pharmaceutical industry, since about 35-40% of newly marketed medications have low water solubility, resulting in poor dissolution and bioavailability, substantial intra- and inter-subject variability, and a lack of dose proportionality. Salt creation, solid dispersion, and complex formation are all strategies that can be used to augment this. For enhancing the solubility of lipophilic medicines, the SelfEmulsifying Drug Delivery System (SEDDS) is gaining attraction. SEDDS are isotropic combinations of one or more hydrophilic solvents and cosolvents/surfactants with the unusual ability to create fine oil-in-water (o/w) micro emulsions after modest agitation and dilution in aqueous media, such as GI fluids. The current review is an updated version of the previous review. SEDDS has progressed in terms of its composition as a result of these advances. Evaluation, various dosage forms, and newer procedures for converting liquid SEDDS to solid, as well as a varietyof uses.

Keywords: Aqueous solubility, Self-Emulsifying Drug Delivery System (SEDDS), Isotropic mixtures.