Sustained Physical Stability of Ibuprofen Sus...

Sustained Physical Stability of Ibuprofen Suspensions Formulated Employing β-Cyclodextrin

Author Name : Chandra Sekhara Rao G, Meghana T, Lahari P, Manasa Ch, Srinivasa Rao Y

ABSTRACT

 Oral aqueous suspensions constitute the largest percentage of pharmaceutical suspensions. They can be easily taken, hence more acceptable in the paediatric and geriatric patient population. They show rapid absorption and superior bioavailability than comparable tablets or capsules. Caking is one of the most difficult problems encountered in the formulation of a suspension. Once the cake is formed it can’t be remedied. However, cake formation can be anticipated and prevented. Incorporation of cyclodextrins to prevent caking tendency and to improve physical stability of suspensions is an ongoing subject of innovation. Five formulations of Ibuprofen suspension including one control and other four containing β-cyclodextrin at increasing levels of concentrations were prepared according to dispersion method. The suspensions were tested for appearance, assay, pH, particle size, viscosity, sedimentation volume and dissolution. Then they are subjected to 21 cycles of freeze-thaw studies and retested for all the above parameters. Freeze-thaw cycling didn’t show any significant change of evaluation parameters like appearance, drug content and pH. Freeze-thaw cycling studies revealed that incorporation of β-cyclodextrin resulted in sustained physical stability of Ibuprofen suspension.

Key Words: β-cyclodextrin, freeze-thaw cycling, Ibuprofen,   physical stability, suspensions.