Synthesis of Coumarin Derivatives and Evaluat...

Synthesis of Coumarin Derivatives and Evaluation of insilico Anti Proliferative Activity by Molecular Docking Study

Author Name : P. Senthil Kumar*, Lakshminarasimhaiah, K. Lakshmi Bhavani

ABSTRACT

Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus. Several methods are available for the preparation of 7-hydroxy 4-methyl coumarins derivatives and have been well documented in the literature. In the present study, the eight new coumarin derivatives are synthesized and characterized by IR and ¹H NMR spectra. The newly synthesized coumarin derivatives were subjected to in silico anti proliferative activity by molecular docking study method. The result of present investigation showed that the compounds (HW1) (HW4) and (HW7) exhibited good in silico anti proliferative activity. However all the remaining synthesized coumarin derivatives show significant in silico activity when compared with reference compound pyrazolo[1,5- a]pyrimidine.

Keywords: Coumarins, Synthesis, Molecular Docking, In silico, Anti Proliferative